Exosome-mediated aptamer S58 reduces fibrosis in a rat glaucoma filtration surgery model
作者：Qian-Yi Lin; Xiang-Ji Li; Yu Leng; Xiao-Min Zhu; Min Tang; Yi Lin; Wang-Du Luo; Bing-Cai Jiang; Xia Chen; Lin Xie
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目的：To confirm whether exosome－mediated delivery of aptamer S58（Exo－S58）has a better antifibrotic effect than naked S58大学在人类过渡期成纤维细胞（HCon Fs）和大鼠青光眼滤过手术（GFS）模型中的应用。方法：To enhance the effective reaction time of aptamer S58 in vivo，通过Pei转移到HEK293T细胞的外体中，以确定Exo－S58对HCFS和大鼠GFS模型的影响。结果：Exo－S58可以显著减少GFS大鼠的细胞促进、migration and fibrosis in TGF－2－induced HCon Fs治疗。结论：外源小体是安全有效的核酸适体载体